The appearance of the building is characterized by a special style consistency and strictness of the composition. In the central part there are paired columns and a pediment with Stroganov's coat of arms.

In 1790, the palace was repeatedly reconstructed according to the project of Andrey Voronikhin. This time, new buildings were created in the style of classicism. The building has its own library, Mineral and Picture rooms. It was here that the real alchemical laboratory — the Physical Room — was located.

Special attention should be paid to the art gallery, which has a huge collection of works by such famous artists as Botticelli, Bechet, Bronzino, Rembrandt and others.