Before the advent of Soviet power, three Armenian churches functioned in Moscow, but after the October Revolution of 1917, only one survived — the Church of the Holy Resurrection. For almost half a century, the building housed a granite workshop, and only in 1956, to the great joy of Armenian believers, the church began to function again.

The church building was erected at the beginning of the 19th century thanks to two Russian patrons, the Lazarev brothers. The outer part of the building assumed a place for candles of believers, which consisted of three parts: on the sides of the central and additional entrances. Also near the church there was a stone stele with the image of a cross, the so-called khachkar. The main entrance to the building was decorated with carved images of angels and saints. The interior of the dome of the church was decorated with images of holy evangelists — the Apostles Matthew, Mark, Luke and John. The altar part was decorated with an icon of the Mother of God, and below was an Armenian shrine, the temple of Zvartnots.

In 1903, a memorial house was erected near the Church of the Holy Resurrection in memory of Isaac Dzhamgarov, a man known for his charitable activities. The full restoration of the temple was carried out in 1997 thanks to the Hayrapetyan brothers.